Everett AS, Pavlidakey PG, Contreras CM, De Los Santos JF, Kim JY, McKee SB, Kaufman HL, and Conry RM. Chronic Granulomatous Dermatitis Induced by Talimogene Laherparepvec Therapy of Melanoma Metastases. J Cutan Pathol. 2017 Sep 22. doi:10.1111/cup.13048.
Rost S, Giltnane J, Bordeaux JM, Hitzman C, Koeppen H, and Liu SD. Multiplexed ion-beam imaging (MIBI) analysis for quantitation of protein expression on cancer tissue sections. Lab Invest. 2017 Aug;97(8):992-1003. doi: 10.1038/labinvest.2017.50.
Blackmon JT, Stratton MS, Kwak Y, Pavlidakev PG, Slominski AT, McKee SB, Viator TM, Kim JY, Huang CC, and Conry RM. Inflammatory melanoma in transit metastases with complete response to talimogene laherparepvec. JAAD Case Reports, 2017 Jun 16;3(4):280-283. doi: 10.1016/j.jdcr.2017.02.011.
Siska PJ, Johnpulle RAN, Zhou A, Bourdeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, and Johnson DB. Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. Oncoimmunology. 2017 Mar 20;6(4):e1305535. doi: 10.1080/2162402X.2017.1305535.
Beckermann KE, Jolly PC, Kim JY, Bordeaux J, Puzanov I, Rathmell WK, and Johnson DB. Clinical and immunologic correlates of response to PD-1 blockade in a patient with metastatic Renal Medullary Carcinoma. J Immunother Cancer. 2017 Jan; 5: 1. doi:10.1186/s40425-016-0206-1
Dakappagari N, Gong H, Pollner R, Siva A, Tangri S, and Lameh J. Application of Biomarkers in Oncology Clinical Trials. Clinical Investigation, 2015; 5(1):61-74.
O'Shannessy DJ, Somers EB, Chandrasekaran LK, Nicolaides NC, Bordeaux J, and Gustavson MD. Influence of tumor microenvironment on prognosis in colorectal cancer: Tissue architecture-dependent signature of endosialin (TEM-1) and associated proteins. Oncotarget. 2014 Jun 30;5(12):3983-95.
Vassilakopoulou M, Togun T, Dafni U, Cheng H, Bordeaux J, Neumeister VM, Bobos M, Pentheroudakis G, Skarlos DV, Pectasides D, Kotoula V, Fountzilas G, Rimm DL, and Psyrri A. In situ quantitative measurement of HER2mRNA predicts benefit from trastuzumab-containing chemotherapy in a cohort of metastatic breast cancer patients. PLoS One. 2014 Jun 26;9(6):e99131. doi: 10.1371/journal.pone.0099131
Bai Y, Cheng H, Bordeaux J, Neumeister V, Kumar S, Rimm DL, and Stern DF. Comparison of HER2 and Phospho-HER2 Expression between Biopsy and Resected Breast Cancer Specimens Using a Quantitative Assessment Method. PLoS One. 2013 Dec 8(11): e79901. doi:10.1371/journal.pone.0079901
Evelyn Diaz; Ju Young Kim; Lisa Adams; Jennifer Bordeaux; Nathan Roscoe; Emmanuel Pacia; Teri Johnson; Thai Tran; Beiru Chen; Bashar Dabbas; Jelveh Lameh; Shabnam Tangri and Naveen Dakappagari. Immuno-Oncology biomarker assessment by novel digital imaging algorithms based on AQUA Technology. National Society for Histotechnology (NHS), Orlando, FL, September 2017. Poster link
Jennifer Bordeaux, Ju Young Kim, Christine Vaupel, David L. Rimm, Thai H Ho, Richard W Joseph, Adil I Daud, Robert M Conry, Elizabeth M Gaughan, Anastasios Dimou, Justin M Balko, James Smithy, John S Witte, Lana McKee, Nicole Dominiak, Bashar Dabbas, Shabnam Tangri, Jelveh Lameh, Jeff Hall and Naveen Dakappagari. Quantitative spatial profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 predicts improved outcomes to anti-PD-1 in metastatic melanoma. American Society of Clinical Oncology (ASCO), Chicago, IL, June 2017. Poster link
Nathan Riccitelli, Ashley Beams, IlaSri Summitt, Jelveh Lameh, and Reinhold Pollner. Analytical Evaluation and Applications of the nCounter Vantage™ RNA:Protein Immune Cell Profiling Panel. Association for Molecular Pathology (AMP); Charlotte, NC, November 2016.
Wenge Shi, Christine Chin, Ashley Beams, Jelveh Lameh, and Reinhold Pollner. Next Generation Sequencing (NGS) Evaluation of CYP11B1 and CYP11B2 Single Nucleotide Variants (SNP) for a Correlation in Hypertension and Cushing Syndrome. American Society of Human Genetics (ASHG), Vancourver BC, October 2016. Poster abstract.
Bordeaux J, Scott LK, Tran T, Chen B, Paulson J, Nguyen V, Tangri S, Lameh J, Dakappagari N. and Kim J. Novel automated quantitative analysis (AQUA) algorithms for reproducible assessment of PD1-PD-L1 interaction and immune cell subsets by multiplex fluorescence immunohistochemistry in cancer immunotherapy trials. Poster at 23rd International Molecular Medicine Tri-Conference, San Francisco, CA, March 2016.
Tran T, Scott K, Singh R, Lee SS, Cogan S, Bordeaux J, Hummel J, Tangri S, Lameh J, Tribouley C, Kassim S, and Dakappagari N. Quantitative multiplexed immunohistochemistry assays for exploring CAR modified T cells and checkpoint inhibitors in lymphoma trials. 57th Annual Meeting of American Society of Hematology (ASH), Orlando, FL, December, 2015. Blood, 2015; 126(23):2659. Poster abstract
Pahuja A, Sarikonda S, Ashok D, Lee B, Graber A, Tangri S, Lameh J, and Dakappagari N. Analytical validation and clinical verification of phosphoprotein biomarker modulation using a novel preservation system-based flow cytometry assay in multiple myeloma clinical trials. AACR 106th Annual Meeting 2015, Philadelphia, PA, April 2015. Cancer Research, 2015; 75(15 suppl):3388. Poster abstract
Sarikonda G, Ashok D, Pahuja A, Lameh J, Tangri S, and Dakappagari N. High complexity flow cytometry panels to monitor target expression, T-cell activation and suppression by novel immunotherapies in hematomalignancy clinical trials. AACR 106th Annual Meeting 2015, Philadelphia, PA, April 2015. Cancer Research, 2015; 75(15 suppl):1302. Poster abstract
Chandrasekaran LK, Bordeaux J, Beruti S, Dakappagari N, Nerenberg M, Lameh J, Graber A, Rimm D, Robbins B, and Rao N. Development of a binary diagnostic immunofluorescence assay by AQUA® technology for accurate detection of HER-2 levels in breast cancer specimens. AACR Annual Meeting 2014, San Diego, CA, April 2014. Cancer Research, 2014; 74:2843. Poster abstract
Bordeaux J, Chandrasekaran K, Beruti S, Nerenberg M, Ramos C, Rimm D, Lameh J, and Dakappagari N. Evaluation of HER2 RNA and Protein Levels in a Large Cohort of Breast Cancer Specimens to Support Development of a Diagnostic Immunofluorescence Assay Quantified by AQUA® Technology. AACR Annual Meeting 2014, San Diego, CA, April 2014. Cancer Research, 2014; 74:2840. Poster Abstract
Shi W, Chin C, Tang T, Hipolito L, Srinivasan P, Chiang D, Peng D, Tomaso ED, Tangri S, Lameh J, and Pollner R. Development of a clinical targeted next-generation sequencing (NGS) test for formalin-fixed paraffin-embedded (FFPE) cancer samples. AACR Annual Meeting 2014, San Diego, CA, April 2014. Cancer Research, 2014; 74:1892. Poster abstract
Tang T, Shi W, Hipolito L, Mayer J, Lameh J, Tangri S, and Pollner R. Development of a nanostring copy number assay for a customized 55 gene panel using challenging formalin-fixed paraffin-embedded (FFPE) tumor samples. AACR Annual Meeting 2014, San Diego, CA, April 2014. Cancer Research, 2014; 74:3734. Poster abstract
Velcheti V, Bordeaux J, Dakappagari N, Pennell N, Stevenson J, Khunger M, Kim JY, Vaupel C, Schalper K, and Rimm D. Quantitative Spatial Profiling of PD-1/PD-L1 Interaction Predicts Response to Adjuvant Chemotherapy in Early Stage Non–Small-Cell Lung Cancer. World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC), Yokohama, Japan, October 2017.
Dakappagari, N. Unique biomarker signatures identified by novel quantitative immunohistochemistry algorithms predict outcomes to PD-1 blockers in metastatic melanoma patients. Immuno-Oncology Summit, Boston, MA, August 2017.
Gong, H. Transforming Oncology Drug Clinical Development by Next Generation Sequencing Testing. American Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference, San Diego, CA, May 2017
Dakappagari, N, Phillips, L, Khan, M, Zhang, H and Amaravadi, A. Biomarker Sample Stability: Why do we Care? Roundtable Session. American Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference, Boston, May 2016.
Bordeaux J, Johnson D, Sosman J, Kim JY, Vaupel C, Dabbas B, Cates J, Hall J, Lameh J, Tangri S, and Dakappagari N. Novel quantitative multiplexed PD-1/PD-L1 immunohistochemistry test provides superior prediction of treatment response in melanoma patients. AACR 107th Annual Meeting 2016, New Orleans, LA, April 2016. Cancer Research, 2016; 76. Abstract link
Lameh J. Development of Bioassays for Checkpoint Immunotherapy. Molecular Medicine Tri Conference Cancer Immunotherapy, San Francisco, March 2016.
Lameh J. Biomarkers to Support the Development and Clinical Application of Immunotherapy Combinations. Molecular Medicine Tri Conference Cancer Immunotherapy, San Francisco, March 2016.
Gong H. Liquid Biopsy: Non-Invasive Tumor Diagnosis and Treatment Monitoring. 5th SABPA Medical Device and Diagnostics (MDD) Forum, San Diego, February 2016.
Lameh J. Biomarkers to Support the Development and Clinical Application of Immunotherapy Combinations. CHI Immunology and Vaccine Summit Rational Combination Cancer Immunotherapy, Boston, August 2015.
Dakappagari, N. Philosophy of Outsourcing Clinical Biomarker Assays. AAPS WORKSHOP on Implementing Biomarkers into drug development, San Francisco, June 2015.
Pollner R. Copy Number Variations: Digital PCR, Nanostring, and Next Generation Sequencing. Digital PCR Conference, San Diego, CA, June 2015.
Oldaker T. The Journey Towards Standardization for Validation of Fluorescent Cell-Based Assays. Oral presentation at International Society of Cell Therapy (ISCT), Las Vegas, NV, May 2015.
Pollner R. Digital PCR for Patient Monitoring and Stratification in Clinical Trials. Molecular Medicine Tri Conference, San Francisco, CA, February 2015.
Gong H. Next Generation of Precision Medicine in Immuno-oncology. Novartis IO APECHO, 2015
Pollner R. Nanostring Assays for Patient Monitoring and Stratification in Clinical Trials. American Society for Human Genetics, 2014, San Francisco.
Lameh J. Applications of Biomarkers in Oncology Clinical Development. Molecular Medicine Tri Conference, 2014
Dakappagari, N. RPMA and AQUA for Evaluation of Biomarker Modulation in Tumors. Roundtable Session. AAPS National Biotechnology Conference, San Diego, May 2013
Gong H. Maximizing Success of Drug Development by Optimal Patient Stratification. AAPS Open Forum, 2013